产品货号：
Z12587
中文名称：
Cathepsin B/CTSB抗体
英文名称：
Anti-Cathepsin B/CTSB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cathepsin B/CTSB Antibody |
| 指标别名 | APP secretase;APPS;cathepsin B;Cathepsin B1;CPSB;CTSB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | CTSB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Cathepsin B/CTSB recombinant protein (Position:Q42-K339). |
| 实际分子量 | 31KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Cathepsin B is an enzymatic protein belonging to the peptidase or protease families.In humans,it is coded by the CTSB gene.And this gene is mapped to chromosome 8p22.The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains,both produced from a single protein precursor.It is a member of the peptidase C1 family.Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients.However,this function is now known to be mediated by BACE1 protease.It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments.Thus,it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.At least five transcript variants encoding the same protein have been found for this gene.The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa. |
| Uniprot ID | P07858 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | cathepsin B |
| 蛋白名全称 | Cathepsin B |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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